Dr. Liu’s laboratory is studying how genetic variants impact gene expression, protein abundance and various levels of regulatory networks, ultimate influence the risks of developing major psychiatric disorders, 治疗反应, as well as related psychological, 行为特征. 由NIH资助, his current projects are about regulatory networks in 基因组学, 表观基因组学, and proteomics of postmortem brains. Multiple advanced sequencing-based technologies, cell biology and 生物信息学 methods are commonly used in this lab to facilitate discovery of risk genes and pathways.

刘春雨，博士简历

教育利益

Training young scientistis with passion and interests to work for improving human life and health.

ASSOCIATIONS / MEMBERSHIPS

American College of Neuropsychopharmacology

American Society of Human Genetics (ASHG)

International Society of Psychiatric Genetics (ISPG)

教育

博士: Hunan Medical University, Hunan, China, 1998, Medical Genetics

研究抽象

Dr. Liu has a long-term interest in understanding of molecular basis of psychiatric diseases. His laboratory participated in one of the bipolar genetics research consortiums and discovered the rare copy number variant (CNV) burden in early-onset bipolar disorder. His lab is one of the leading research groups on genome-wide study of postmortem brain gene expression and DNA methylation, pioneered in study of gene expression regulatory network in human brain. He established the methylation quantitative trait loci (mQTLs) in human brain, indicating that DNA methylation of some sequences could be highly regulated by genetic variants. His lab currently focuses more on understanding genomic and epigenomic mechanisms in human brains for psychiatric disorders. His research has been supported by NIMH, NARSAD, and Brain 研究 Foundation. He has published more than 100 peer-reviewed papers and several book chapters, and been cited for more than 7,000倍, h指数为37. He has served as reviewer for dozens of journals and foundations including NIH. Dr. Liu’s major research focuses on using a comprehensive approach that is composed of genetics, 生物信息学, 基因组学, cellular and animal models to identify the molecular mechanisms of major psychiatric diseases, particularly bipolar disorder and schizophrenia. Constructing multidimensional regulatory network in human brains, and relating that to etiology and pathology of mental illness is the major mission of this lab.

Current major NIH-funded project is the psychENCODE project, investigating multi-dimensional biological features, networks in brains of bipolar disorder, schizophrenia and normal.